A bunch of friends hit that tricky midlife moment and feel kinda blah about life. So, they decide to spice things up by remaking a movie they loved when they were kids. Doug (played by Jack Black) and Griff (played by Paul Rudd) are tight—like, best buds forever. They’ve always wanted to remake their favorite flick, Anaconda. Finally, they say, “Why not now?” and head to the Amazon to start shooting.

But hey, it’s not all fun and games out there! Just as they’re getting into the groove of things, a very real—and very huge—anaconda crashes their set. Suddenly it’s not just about making a fun film; it’s also about surviving in this jungle that now feels way too lifelike. What started as an adventure quickly turns wild and dangerous. Fun times ahead? More like run for your life!