Dr. Nate Daniels returns to South Africa, where he once met his late wife, to spend a long-planned vacation with his two daughters at a nature reserve run by old friend Martin Battles. family, wildlife biologist. But this saving rest will turn into a test of survival when a lion thirsting for revenge, the only survivor of the bloodthirsty hunt of vile poachers, begins to devour any human on his way and chases the doctor and his family.